“Practice Parameter: Treatment of Nervous System Lyme Disease” (Endorsed by IDSA)

Neurology 2007; 69:91-102

Lyme disease is a multisystem infectious disease caused by the tick-borne spirochete Borrelia burgdorferi, which frequently affects the nervous system. Published guidelines are available to assist in the diagnosis of nervous system Lyme disease, and for treatment of Lyme disease in general. However, there continues to be considerable controversy and uncertainty about the best approach to treatment of neuroborreliosis.

Clinical Infectious Diseases 2006; 43:1089–134

Lyme disease is the most common tick-borne infection in both North America and Europe. In the United States, Lyme disease is caused by Borrelia burgdorferi, which is transmitted by the bite of the tick species Ixodes scapularis and Ixodes pacificus. Clinical manifestations most often involve the skin, joints, nervous system, and heart.