Mechanisms of receptor tyrosine kinase activation in cancer Zhenfang Du & Christine M. Lovly Molecular Cancer volume 17, Article number: 58 (2018) Derlemeye ulaşmak için tıklayınız Receptor tyrosine kinases (RTKs) play an important…
Cancer: Sugar-coated cell signalling Andrew J. Ewald & Mikala Egeblad Nature (2014) doi:10.1038/nature13506 Cell membranes are covered with sugar-conjugated proteins. New findings suggest that the physical properties of this coating, which is more…
The Long Journey of Cancer Biomarkers from the Bench to the Clinic Maria P. Pavlou, Eleftherios P. Diamandis and Ivan M. Blasutig Clinical Chemistry January 2013 vol. 59 no. 1 147-157 BACKGROUND: Protein…
Searching for consistently reported up- and down-regulated biomarkers in colorectal cancer: a systematic review of proteomic studies Ma Y, Zhang P, Wang F, Qin H. Mol Biol Rep. 2012 Aug;39(8):8483-90. Epub 2012 Jun…
Aging, immunity, and cancer Fulop T, Larbi A, Kotb R, de Angelis F, Pawelec G. Discov Med. 2011 Jun;11(61):537-50. Abstract Age is the most important risk factor for tumorigenesis. More than 60% of…
PCR-Based Methods for Detecting Single-Locus DNA Methylation Biomarkers in Cancer Diagnostics, Prognostics, and Response to Treatment Lasse Sommer Kristensen and Lise Lotte Hansen Clinical Chemistry. 2009;55:1471-1483 Background: DNA methylation is a highly characterized…
Transforming Growth Factor-betanın Kanserde Baskılayıcı Rolü Pervin Vural Türk Klinik Biyokimya Derg 2010; 8(1): 35-42 Transforming Growth Factor- beta (TGF-beta) doku homeostazının sürdürülmesinde önemli rol oynamaktadır. TGFbeta sinyalizasyon yolunun bozulması kanserde büyük önem…
KANSERLİ HÜCRE DAVRANIÞININ MOLEKÜLER TEMELLERİ APOPTOZ ÜZERİNE ETKİ EDEN FAKTÖRLER Prof. Dr. Semra KOÇTÜRK Apoptoz fizyolojik şartlardaki çok hücreli organizmalarda, hem gelişim sırasında hem de gelişimini tamamlamış organizmaların homeostazının sağlanmasında istenmeyen hücrelerin yok…
Cellular Senescence in Cancer and Aging Manuel Collado, Maria A. Blasco and Manuel Serrano Cell, Volume 130, Issue 2, 223-233, 27 July 2007 Cellular senescence, a state of irreversible growth arrest, can be…