Essays In Biochemistry
Dec 03, 2018,62(5)619-642;DOI: 10.1042/EBC20170054

This article gives the reader an insight into the role of biochemistry in some of the current
global health and disease problems. It surveys the biochemical causes of disease in an
accessible and succinct form while also bringing in aspects of pharmacology, cell biology,
pathology and physiology which are closely aligned with biochemistry. The discussion of the
selected diseases highlights exciting new developments and illuminates key biochemical
pathways and commonalities. The article includes coverage of diabetes, atherosclerosis,
cancer, microorganisms and disease, nutrition, liver disease and Alzheimer’s disease, but
does not attempt to be comprehensive in its coverage of disease, since this is beyond its
remit and scope. Consequently there are many fascinating biochemical aspects of diseases,
both common and rare, that are not addressed here that can be explored in the further
reading cited. Techniques and biochemical procedures for studying disease are not covered
in detail here, but these can be found readily in a range of biochemical methods sources.

•Action Potential

•Biochemical Pathway

•Changes in the Partial Pressures

•Cotransport (Symport & Antiport)

•Electron Transport System and ATP Synthesis

•Energy Sources for Prolonged Exercise

•Enzyme Action and the Hydrolysis of Sucrose

•Electron Transport System and Formation of ATP

•Hormonal Communication

•Glycolysis Animation

•Krebs Cycle Animation

•NAD Animation

•Membrane Bound Receptors

•Myofilament Contraction

•Positive and Negative Feedback

•Protein Denaturation

•Proton Pump

•Seconder Messengers

•Signal Amplification

•Sodium-Potassium Exchange Pump

•Steroid Hormone

•Thyroid Hormone

•Voltage Gated Ion Channels

Carbohydrates Link
Proteins Link
Nucleic Acids Link
Lipids Link
Enzymes Link
Krebs Cycle Link
Electron Transport Chain Link
Hemoglobin and Oxygen Binding Link

This site is designed to provide in-depth knowledge of diseases caused by various errors in metabolism. The site is designed to provide students an opportunity to learn more about these diseases, their causes and treatment, by working through different clinical case examples.

Amino Acid Metabolism
Vitamin Deficiencies
Carbohydrate Metabolism
Alcoholism

Link için tıklayınız
ANIMATIONS AND INFORMATION
Cell Structure
http://www.sci.sdsu.edu/TFrey/MitoMovie.htm (Mitochondria)

http://www.scripps.edu/pub/goodsell/gallery/patterson.html (Panoramic Cell View)

http://www.sci.sdsu.edu/class/bio590/movies/cell_motility1.html (Cell Motility)

http://www.bioanim.com/CellTissueHumanBody6/index.html (Cell Structure Overview)

Chirality movie

http://cwx.prenhall.com/petrucci/medialib/media_portfolio/text_images/083_Chirality.MOV

Transient hydrogen bonding of water

http://www.stolaf.edu/people/giannini/flashanimat/water/water.swf

Buffers: Weak Acids and water

http://www.stolaf.edu/people/giannini/flashanimat/water/weakacid.swf

http://www.chembio.uoguelph.ca/educmat/chm19104/chemtoons/chemtoons.htm

Animation Of Peptide Bond Formation

http://www.specialedprep.net/MSAT%20SCIENCE/Cellular%20Biology/Proteins1.htm#HOW

Peptide Bonds Have Double Bond Character

http://www.mcphu.edu/netbiochem/movies/peptresn.mov

Peptide Rotation Movie

http://cwx.prenhall.com/horton/chapter4/deluxe.html

CHIME Models of Hemoglobin and Sickle Hemoglobin

http://www.umass.edu/microbio/chime/hemoglob/index.htm

Electron microscopy picture of Fibrils:

http://gingi.uchicago.edu/

Secondary Structural Elements

Right-Handed Alpha Helix

http://www.cem.msu.edu/~parrill/movies/right.mov

Anti-Parallel Beta Sheet

http://www.cem.msu.edu/~parrill/movies/sheet.mov

http://www.cem.msu.edu/~parrill/movies/parallel.mov

Protein Organization: Primary to Quaternary Structure

http://www.biochem.arizona.edu/classes/bioc462/462a/NOTES/Protein_Structure/motif_txt.htm
http://bmbiris.bmb.uga.edu/8010/moremen/weblinks/efhand/efhand.html

Protein Folding Interactive Animation:

http://www.wiley.com/legacy/college/boyer/0470003790/animations/animations.htm

Protein Techniques:

http://www.wiley.com/college/fob/anim/index.html

Glucose binding to hexokinase:
http://www.biochem.arizona.edu/classes/bioc462/462bH2002/mol/chime/hexokin/hexokin.html

Interactive Animation: Enzyme Specificity and Binding Models

http://www.boyerbiochem.com

Enzyme Kinetics:

http://cwx.prenhall.com/horton/chapter5/deluxe.html

More animations:

http://www.wiley.com/college/fob/anim/#chap3

glycolysis

http://www.biocarta.com/pathfiles/h_glycolysisPathway.asp

TCA Cycle Animations

http://www.wiley.com/college/fob/anim/

http://www.wiley.com/legacy/college/boyer/0470003790/animations/animations.htm

http://www.wiley.com/college/pratt/0471393878/student/exercises/index.html

More Electron Transport Chain and Oxidative Phosphorylation Animation Websites:

1. http://www.cat.cc.md.us/biotutorials/cellresp/etsar.html

2. http://wunmr.wustl.edu/EduDev/LabTutorials/Cytochromes/etc_movie.html

3. http://faculty.nl.edu/jste/electron_transport_system.htm

4. http://cwx.prenhall.com/horton/chapter14/deluxe.html

5. http://www.wiley.com/college/fob/anim/

6. Great site with lots of information:

http://www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/animations/oxidative/oxidativephosphorylation.html

7. http://www.science.smith.edu/departments/Biology/Bio111/etc.html

8. http://www.stolaf.edu/people/giannini/biological%20anamations.html

Wiley.com have produced this online resource for Biochemistry and the Chemistry of Life, and it contains a whole load of interactives and animations.

It is an ideal resource for: photosynthesis, respiration, DNA replication, transcription, translation, cell structure, enzymes and protein synthesis.

http://www.wiley.com/legacy/college/boyer/0470003790/animations/animations.htm

Carbohydrate Metabolism
Glycolysis (3-D)
Glycolysis & Gluconeogenesis (3-D)
Kreb’s – TCA – Citric Acid Cycle (3-D)
Pentose Phosphate Pathway (3-D)
Glycogen Biosynthesis & Galactose Pathway (3-D)
Calvin Cycle

Lipid Metabolism
Triacylglycerol Metabolism
Activation of Fatty Acids (3-D)
Beta-Oxidation of Fatty Acids — even chain
Beta-Oxidation of Fatty Acids — odd chain (3-D)
Beta-Oxidation of Polyunsaturated Fatty Acid (3-D)
Alpha-Oxidation Pathway
De Novo Biosynthesis of Fatty Acids
Cholesterol Biosynthesis 1

Amino Acid Metabolism
Glutamate Reactions
Kreb-Henseleit Urea Cycle (3-D)
Shikimate Pathway
Phenylalanine and Tyrosine Biosynthesis
Tryptophan Biosynthesis

Energy Metabolism
Oxidative Phosphorylation
Chemistry of ATP Synthesis
Photosynthesis
Methane Metabolism

Coenzymes (3-D) (2-D & 3-D)

Link için tıklayınız

Protein sentezi Link için tıklayınız

Apopitoz ve nekroz animasyonlarıLink için tıklayınız

DNA replikasyonu Link için tıklayınız

Introducing a gene to a cell Link için tıklayınız

Citric Acid Cycle ExerciseLink için tıklayınız

Fatty Acid Activation and Transport Link için tıklayınız

Muscle Contraction Animation and Exercise Link için tıklayınız

Nucleic Acids Memorization Game Link için tıklayınız

Oxidative PhosphorylationLink için tıklayınız

Protein Synthesis Animation and Exercise Link için tıklayınız

The Pyruvate Dehydrogenase Complex Link için tıklayınız

Biochemical Pathways Link için tıklayınız

The Sodium/Potassium Ion Pump Link için tıklayınız

Coagulation. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Critical care. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Diagnosis and management of diabetes mellitus. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Drugs and ethanol. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Infectious disease. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Intraoperative parathyroid hormone. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Management. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

National Academy of Clinical Biochemistry and IFCC Committee for standardization of markers of cardiac damage laboratory medicine practice guidelines: Analytical issues for biochemical markers of acute coronary syndromes

National Academy of Clinical Biochemistry and IFCC Committee for standardization of markers of cardiac damage laboratory medicine practice guidelines: Analytical issues for biomarkers of heart failure

National Academy of Clinical Biochemistry laboratory medicine practice guidelines: Clinical utilization of cardiac biomarker testing in heart failure

National Academy of Clinical Biochemistry laboratory medicine practice guidelines: Clinical characteristics and utilization of biochemical markers in acute coronary syndromes

National Academy of Clinical Biochemistry laboratory medicine practice guidelines: Point of care testing, oversight and administration of cardiac biomarkers for acute coronary syndromes

National Academy of Clinical Biochemistry laboratory medicine practice guidelines: Use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type Natriuretic Peptide for Etiologies other than acute coronary syndromes and heart failure

Occult blood. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

pH testing. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Recommendations for the use of laboratory tests to support poisoned patients who present to the emergency department

Renal function testing. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Reproductive testing. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Transcutaneous bilirubin testing. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing

Use of cardiac biomarkers for acute coronary syndromes. Laboratory medicine practice guidelines: evidence-based practice for point-of-care testing