Interactive Hematology
An approach to common problems
Approach to the diagnosis of anemia
Approach to diagnosis of different types of anemia
Diagnostic blood and marrow smears
Approach to abnormal leukocyte counts
Approach to abnormal platelet counts
Approach to venous thromboembolism
Disease mechanisms and cell biology
– aplastic anemia and pancytopenia
– molecular biology of acute leukemia
Specific diseases
Erythrocytes
– iron deficiency, absorption, transport etc
Acute Leukemia
-acute lymphocytic leukemia (ALL)
-acute myelogenous leukemia (AML)
-acute promyelocytic leukemia (APL)
– minimal residual disease (MRD)
– stem cell transplantation (SCT) in AML
Lymphocytic neoplasms
-chronic lymphocytic leukemia (CLL)
-follicular cell lymphoma (FCL)
-introduction to peripheral T-cell lymphoma (PTCL)
Indolent stem cell neoplasms
– chronic myelogenous leukemia (CML)
– inatinib mesylate (targeted Rx for CML
– myeloproliferative disorders (MPD)
– polycythemia rubra vera (PRV)
– essential thrombocytosis (ET)
– myelofibrosis with myeloid metaplasia (MMM)
– myelodysplastic syndromes (MDS)
Hemostatic disorders
-Anti-phospholipid antibody syndrome
– Heparin induced thrombocytopenia (HIT)
-Thrombotic thrombocytopenic purpura (TTP)
Targeted Therapy
-antisense oligonucleotides (anti BCL-2)
– thalidomide and Lenalidomide
– vascular endothelial growth factor (VEGF)
CASE STUDIES
– microcytic anemia in a marathon runner
– anemia in a patient with a chronic disease (ACD)
– fatigue and bruising in a mechanic
– ALL in a male aged 3 in 1966
– Hodgkin’s disease in a young boy
– Peripheral T – cell lymphoma- 5 cases
– Fatigue and bruising in an auto mechanic
– Vignettes- complications of polycythemia vera
Future Directions on Malignant Disease