Adipokines in obesity

Adipokines in obesity
Viviane de Oliveira Leal, Denise Mafra

Clinica Chimica Acta Volume 419, 18 April 2013, Pages 87–94

White adipose tissue is recognized as a dynamic endocrine organ able to produce and release several bioactive polypeptides known as adipokines. Obesity is defined as an excessive growth of adipose tissue. As such, it is likely that adipokines could play an important role in the development of diseases associated with obesity including insulin resistance, inflammation, hypertension, cardiovascular risk and metabolic disorders. This review focuses on obesity specific-adipokine profiles and the role of some adipokines in obesity-related metabolic disorders.

Highlights

► Obesity is defined as an excessive growth of adipose tissue. ► White adipose tissue expresses and secretes several bioactive polypeptides, known as adipokines. ► In the obese state, adipokines play a central role in the developing of obesity-related metabolic disorders.