Performance of the Cockcroft-Gault, MDRD, and New CKDEPI Formulas in Relation to GFR, Age, and Body Size

Performance of the Cockcroft-Gault, MDRD, and New CKDEPI Formulas in Relation to GFR, Age, and Body Size
Wieneke Marleen Michels,*† Diana Carina Grootendorst,† Marion Verduijn,†

Clin J Am Soc Nephrol 5: 1003–1009, 2010

Background and objectives: We compared the estimations of Cockcroft-Gault, Modification of Diet in Renal Disease
(MDRD), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations to a gold standard GFR measurement
using 125I-iothalamate, within strata of GFR, gender, age, body weight, and body mass index (BMI).
Design, setting, participants, & measurements: For people who previously underwent a GFR measurement, bias, precision,
and accuracies between measured and estimated kidney functions were calculated within strata of the variables. The relation
between the absolute bias and the variables was tested with linear regression analysis.
Results: Overall (n
271, 44% male, mean measured GFR 72.6 ml/min per 1.73 m2 [SD 30.4 ml/min per 1.73 m2]), mean bias
was smallest for MDRD (P < 0.01). CKD-EPI had highest accuracy (P < 0.01 compared with Cockcroft-Gault), which did not differ from MDRD (P
0.14). The absolute bias of all formulas was related to age. For MDRD and CKD-EPI, absolute bias was also related to the GFR; for Cockcroft-Gault, it was related to body weight and BMI as well. In all extreme subgroups, MDRD and CKD-EPI provided highest accuracies. Conclusions: The absolute bias of all formulas is influenced by age; CKD-EPI and MDRD are also influenced by GFR. Cockcroft-Gault is additionally influenced by body weight and BMI. In general, CKD-EPI gives the best estimation of GFR, although its accuracy is close to that of the MDRD.