An early history of T cell-mediated cytotoxicity.

An early history of T cell-mediated cytotoxicity.

Nat Rev Immunol. 2018 Aug;18(8):527-535. doi: 10.1038/s41577-018-0009-3.

Golstein P1, Griffiths GM2.
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Abstract
After 60 years of intense fundamental research into T cell-mediated cytotoxicity, we have gained a detailed knowledge of the cells involved, specific recognition mechanisms and post-recognition perforin-granzyme-based and FAS-based molecular mechanisms. What could not be anticipated at the outset was how discovery of the mechanisms regulating the activation and function of cytotoxic T cells would lead to new developments in cancer immunotherapy. Given the profound recent interest in therapeutic manipulation of cytotoxic T cell responses, it is an opportune time to look back on the early history of the field. This Timeline describes how the early findings occurred and eventually led to current therapeutic applications.